BDBM474405 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(tetrahydro-2H-pyran-3-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate ::US10858373, Example 3

SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CC1CCCOC1)CCO2)C(F)(F)F

InChI Key InChIKey=CFEDICYKQGDLCA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474405   

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474405(US10858373, Example 3 | 1,1,1,3,3,3-Hexafluoroprop...)
Affinity DataIC50: 59.9nMAssay Description:Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474405(US10858373, Example 3 | 1,1,1,3,3,3-Hexafluoroprop...)
Affinity DataIC50: 8.49nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent