BDBM474364 (S)-6-benzhydryl-3-(difluoromethyl)-11- hydroxy-5,6-dihydro-10H-imidazo[1,2- a]pyrido[2,1-c]pyrazin-10-one::US10858366, Example 57::US11453677, Example 57

SMILES Oc1c2-c3ncc(C(F)F)n3C[C@H](C(c3ccccc3)c3ccccc3)n2ccc1=O

InChI Key InChIKey=LMFJYRUSAPMAGM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474364   

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474364(US10858366, Example 57 | (S)-6-benzhydryl-3-(diflu...)
Affinity DataIC50: 40nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474364(US10858366, Example 57 | (S)-6-benzhydryl-3-(diflu...)
Affinity DataIC50: 40nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent