BDBM474359 3-((S)-(4-fluorophenyl)((S)-11-hydroxy-10- oxo-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-6- yl)methyl)benzonitrile::US10858366, Example 43::US11453677, Example 43

SMILES Oc1c2-c3nccn3C[C@H]([C@@H](c3ccc(F)cc3)c3cccc(c3)C#N)n2ncc1=O

InChI Key InChIKey=QBDXTNNBUQMTRK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474359   

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474359(US10858366, Example 43 | 3-((S)-(4-fluorophenyl)((...)
Affinity DataIC50: 20nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474359(US10858366, Example 43 | 3-((S)-(4-fluorophenyl)((...)
Affinity DataIC50: 20nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent