BDBM474338 (R)-7-(4-fluorophenyl)-8-(3-methylimidazo[l,2- a]pyrdin-6-yl)-2-((1-methylpyrrolidin-2-yl )meth yl)-[l,2,4]triazolo[l,5-c]pyrimidin-5-amine::US10858365, Compound 125

SMILES CN1CCC[C@@H]1Cc1nc2c(-c3ccc4ncc(C)n4c3)c(nc(N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=BFJGLGUWQKURET-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474338   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474338(US10858365, Compound 125 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 0.400nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474338(US10858365, Compound 125 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 34.1nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent