BDBM474317 8-(3-methyiimidazo[l,2-a]pyridin-6-yl)-7-(oxazo l-2-yl)-2-((tetrahydrofuran-2-yl)methyl)-[l,2,4] triazolo[l,5-c]pyrimidin-5-amine (isomer 1)::US10858365, Compound 106-1

SMILES Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(C[C@@H]3CCCO3)nc12)-c1ncco1

InChI Key InChIKey=HXUYNIIAUKDHMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474317   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474317(US10858365, Compound 106-1 | 8-(3-methyiimidazo[l,...)
Affinity DataIC50: 0.5nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474317(US10858365, Compound 106-1 | 8-(3-methyiimidazo[l,...)
Affinity DataIC50: 53.2nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent