BDBM474314 (R)-7-(4-fluorophenyl)-8-(1-methyl-1H-benzo[d] imidazol-6-yl)-2-((l-methylpyrrolidin-2-yl)meth yl)-[l,2,4]triazolo[1,5-c]pyrimidin-5-amine::US10858365, Compound 104

SMILES CN1CCC[C@@H]1Cc1nc2c(-c3ccc4ncn(C)c4c3)c(nc(N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=OONYUIKMLKLQPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474314   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474314(US10858365, Compound 104 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 1nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474314(US10858365, Compound 104 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 1.63E+3nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474314(US10858365, Compound 104 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 5.70nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474314(US10858365, Compound 104 | (R)-7-(4-fluorophenyl)-...)
Affinity DataIC50: 34.1nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent