BDBM474310 2-((3*fluoropyridin-2-yl)methyl)-N7,N7-dimethy l-8-(3-methylimidazo[1,2-a]pyridin-6-yl)-[1,2,4] triazolo[1,5-c]pyrimidine-5,7-diamine::US10858365, Compound 100

SMILES CN(C)c1nc(N)n2nc(Cc3ncccc3F)nc2c1-c1ccc2ncc(C)n2c1

InChI Key InChIKey=OOAGAXDDBFJMBM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474310   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474310(US10858365, Compound 100 | 2-((3*fluoropyridin-2-y...)
Affinity DataIC50: 1.20nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474310(US10858365, Compound 100 | 2-((3*fluoropyridin-2-y...)
Affinity DataIC50: 38nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474310(US10858365, Compound 100 | 2-((3*fluoropyridin-2-y...)
Affinity DataIC50: 3.5nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474310(US10858365, Compound 100 | 2-((3*fluoropyridin-2-y...)
Affinity DataIC50: 11.8nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent