BDBM474289 8-(1H-benzo[d]imidazol-6-yl)-7-(4-fluorophenyl)- 2-((3-fluoropyridin-2-yl)methyl)-[1,2,4]triazolo [l,5-c]pyrimidin-5-amine::US10858365, Compound 75

SMILES Nc1nc(-c2ccc(F)cc2)c(-c2ccc3nc[nH]c3c2)c2nc(Cc3ncccc3F)nn12

InChI Key InChIKey=RMURIFHLAMKRDR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474289   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474289(US10858365, Compound 75 | 8-(1H-benzo[d]imidazol-6...)
Affinity DataIC50: 1.70nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474289(US10858365, Compound 75 | 8-(1H-benzo[d]imidazol-6...)
Affinity DataIC50: 38nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474289(US10858365, Compound 75 | 8-(1H-benzo[d]imidazol-6...)
Affinity DataIC50: 17nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474289(US10858365, Compound 75 | 8-(1H-benzo[d]imidazol-6...)
Affinity DataIC50: 31nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent