BDBM474252 8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2-((3-fluoropyridin-2-yl)methyl)-[1,2,4]triazolo [1,5-cjpyrimidin-5-amine::US10858365, Compound 14

SMILES Cc1cc(cc(C)n1)-c1c(nc(N)n2nc(Cc3ncccc3F)nc12)-c1ccc(F)cc1

InChI Key InChIKey=YXMOEFODDQFQNL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 474252   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474252(8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2...)
Affinity DataIC50: 6.90nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474252(8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2...)
Affinity DataIC50: 2.24E+3nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474252(8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2...)
Affinity DataIC50: 18nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474252(8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2...)
Affinity DataIC50: 97nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A3(Human)
TBA

US Patent
LigandPNGBDBM474252(8-(2,6-dimethyIpyridin-4-yl)-7-(4-fluorophenyl)- 2...)
Affinity DataIC50: 1.00E+4nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent