BDBM474226 5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl)-1-methyl pyridin-2(lH)-one::US10858365, Compound 22::US11629147, Cmpd. 22

SMILES Cn1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3c(F)cccc3F)nc12)-c1ncco1

InChI Key InChIKey=IDPLEAPGHSRRKF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474226   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 12nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 6.80nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 8.20nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 168nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 12nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 25nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 12nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474226(5-(5-amino-2-(2,6-difluorobenzyl)-7-(oxazol-2- y1)...)
Affinity DataIC50: 6.80nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent