BDBM474200 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiazol-4- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 80::US10912773, Example 80::US11472810, Example 80

SMILES Cc1cn2c(ncc2c(=O)n1Cc1cscn1)C1CCOCC1

InChI Key InChIKey=SQDRHBKRJBDLOC-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 474200   

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 1.31E+3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 496nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 1.31E+3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 496nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 228nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 112nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 1.31E+3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 496nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 228nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 112nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 1.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474200(US10912773, Example 80 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 496nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent