BDBM474192 (R)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 72::US10912773, Example 72::US11472810, Example 72

SMILES COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H](C)c2ccccc2)cc1

InChI Key InChIKey=SWHFTCTZWOUUQD-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474192   

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474192(US10912773, Example 72 | (R)-7-(4-methoxybenzyl)-6...)
Affinity DataIC50: 43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent