BDBM474190 7-(4-methoxybenzyl)-6-methyl-3- ((1R,2R,4S)-2-methyl-7- oxabicyclo[2.2.1]heptan-2- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 70::US10912773, Example 70::US11472810, Example 70

SMILES COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CC3CCC2O3)cc1

InChI Key

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474190   

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474190(US10912773, Example 70 | 7-(4-methoxybenzyl)-6-met...)
Affinity DataIC50: 28nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent