BDBM474182 7-(cyclopentylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 63::US10912773, Example 63::US11472810, Example 63

SMILES Cc1cn2c(ncc2c(=O)n1CC1CCCC1)C1CCOCC1

InChI Key InChIKey=IVIOKHSMYSCNPJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474182   

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 183nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 82nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 183nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 82nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 183nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 82nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 183nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 82nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474182(US10912773, Example 63 | 7-(cyclopentylmethyl)-6-m...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent