BDBM474151 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10858362, Example 36, isomer 3::US10912773, Example 36-isomer-3::US11472810, Example 36, isomer 2

SMILES C[C@@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O

InChI Key InChIKey=BZFPDTIGFMRZDI-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474151   

LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 77nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 282nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 107nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 38nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 77nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 282nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 107nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM474151(US10912773, Example 36-isomer-3 | 7-(3-fluorobenzy...)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent