BDBM474132 6-Methyl-7-(3-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 25::US10912773, Example 25::US11472810, Example 25

SMILES Cc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1

InChI Key InChIKey=FCLGCXKNDLJHGE-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474132   

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 63nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 57nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 63nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 57nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 63nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 57nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 63nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
Affinity DataIC50: 57nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474132(US10912773, Example 25 | 6-Methyl-7-(3-methylbenzy...)
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent