BDBM474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15

SMILES Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1

InChI Key InChIKey=JVYBBFBHTBCHNY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474122   

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 115nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

LigandPNGBDBM474122(US10912773, Example 15 | 6-Bromo-7-(3-fluorobenzyl...)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent