BDBM474104 1'-(6-amino-5-((2-amino-3-chloropyridin- 4-yl)thio)pyrazin-2-yl)spiro[bicyclo[3.1.0] hexane-3,4'-piperidin]-2-amine::US10858359, Example 74

SMILES NC1C2CC2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1

InChI Key InChIKey=YAPXLZOGUIFJFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474104   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474104(1'-(6-amino-5-((2-amino-3-chloropyridin- 4-yl)thio...)
Affinity DataIC50: 8.30nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474104(1'-(6-amino-5-((2-amino-3-chloropyridin- 4-yl)thio...)
Affinity DataIC50: 8.30nMAssay Description:Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed