BDBM474103 (S)-8-(6-amino-5-((3-fluoro-1H-indol-4-yl) thio)pyrazin-2-yl)-2-oxa-8-azaspiro[4.5] decan-4-amine::US10858359, Example 40

SMILES N[C@@H]1COCC11CCN(CC1)c1cnc(Sc2cccc3[nH]cc(F)c23)c(N)n1

InChI Key InChIKey=ARNQLTMQEHGOFF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474103   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474103((S)-8-(6-amino-5-((3-fluoro-1H-indol-4-yl) thio)py...)
Affinity DataIC50: 40.6nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent