BDBM474023 6-(8-Aminoimidazo[1,2-a]pyrazin-3-yl)-2-[(1S)-1-cyclopropylethyl]-N- methyl-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10858355, Example 31

SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2c(N)nccn12

InChI Key InChIKey=SJEXQETYPPZBHL-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474023   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Astrazeneca

US Patent

LigandBDBM474023(6-(8-Aminoimidazo[1,2-a]pyrazin-3-yl)-2-[(1S)-1-cy...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/11/2021
Entry Details
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