BDBM473725 N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]pyridin-2-yl)pyrazolo[3,4- d]pyrimidin-1- yl]cyclohexyl]cyclopropanecarboxamide::US10844067, Example 68::US11661423, Example 68

SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CC[C@@H](CC1)NC(=O)C1CC1

InChI Key InChIKey=QFOYXEGQTWGLCJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473725   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 2nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 1.14E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 31.9nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 2nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 1.14E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473725(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Affinity DataIC50: 31.9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent