BDBM473723 3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cyclobutyl-pyrazolo[3,4-d]pyrimidin-4- amine::US10844067, Example 66::US11661423, Example 66

SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCC1

InChI Key InChIKey=VIXPEXLAHSLEGV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473723   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 3.40nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 1.87E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 32.3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 3.40nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 1.87E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473723(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Affinity DataIC50: 32.3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent