BDBM473708 1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]pyridin-2-yl)-1H- pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 51::US11661423, Example 51

SMILES CC(C)(C)n1nc(-c2[nH]c3ncc(Cl)cc3c2Cl)c2c(N)ncnc12

InChI Key InChIKey=RAPKNCDMEMAPPY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473708   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 19.2nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 5.24E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 123nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 19.2nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 5.24E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473708(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 123nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent