BDBM473703 3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethyl-pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 46::US11661423, Example 46

SMILES CCn1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12

InChI Key InChIKey=DNKHTUXQNXCLRA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473703   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 4.40nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 6.40E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 98.1nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 4.40nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 6.40E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473703(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Affinity DataIC50: 98.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent