BDBM473697 3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrazolo[3,4-d]pyrimidin-1- yl]cyclopentanol::US10844067, Example 40::US11661423, Example 40

SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CCC(O)C1

InChI Key InChIKey=OFXSDEOZNJESCC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 473697   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473697(3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyraz...)
Affinity DataIC50: 4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473697(3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyraz...)
Affinity DataIC50: 734nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473697(3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyraz...)
Affinity DataIC50: 4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473697(3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyraz...)
Affinity DataIC50: 734nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent