BDBM473694 1-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 37::US11661423, Example 37

SMILES CC(C)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12

InChI Key InChIKey=ZTEFVJQXBWSFIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473694   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473694(1-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyra...)
Affinity DataIC50: 3.10nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473694(1-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyra...)
Affinity DataIC50: 3.10nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent