BDBM473690 3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isopropyl-1H-pyrazolo[4,3-c]pyridin-4- amine::US10844067, Example 33::US11661423, Example 33

SMILES CC(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)nccc12

InChI Key InChIKey=QCOUFOILFGCFOO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473690   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 2.90nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 584nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 43.9nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 2.90nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 584nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473690(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Affinity DataIC50: 43.9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent