BDBM473679 1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo[2,3-b]pyridin-2-yl}-1H- pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 22::US11661423, Example 22

SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12

InChI Key InChIKey=IFMCEWXRLHTEPH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473679   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 9nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 9.49E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 3.00E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 9.49E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473679(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Affinity DataIC50: 3.00E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent