BDBM473664 3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinocyclohexyl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine::US10844067, Example 7::US11661423, Example 7

SMILES Nc1ncnc2n(nc(-c3[nH]c4ccccc4c3Cl)c12)C1CC[C@@H](CC1)N1CCOCC1

InChI Key InChIKey=WPPSTXPPFUMOBW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473664   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 25.3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 2.61E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 188nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 25.3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 2.61E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM473664(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Affinity DataIC50: 188nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent