BDBM473178 US10844038, Example 39::US10844038, Example 40::trans 1-((4-(Benzyloxy)-1,2-dithiolan-3-yl)methyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SMILES Nc1ncnc2n(CC3SSCC3OCc3ccccc3)nc(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=ADPWNOVNIYYWDN-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 473178   

TargetTyrosine-protein kinase BTK(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  5.50E+3nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  750nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fyn(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent