BDBM472850 (R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-1-(3-phenyl-3,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-propan-1-one (A43)::US10829489, Compound A43

SMILES C[C@@](O)(C(=O)N1CCc2c(C1)ncn2-c1ccccc1)C(F)(F)F

InChI Key InChIKey=IYNFKJAKDZLOJR-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 472850   

LigandPNGBDBM472850((R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-1-(3-phenyl...)
Affinity DataIC50: 1.65E+3nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
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LigandPNGBDBM472850((R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-1-(3-phenyl...)
Affinity DataKd: <300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent