BDBM472678 2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6',6a',8',9'- tetrahydrospiro[cyclopentane- 1,10'- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine]-5',7'-dione::US10829490, Cmpd # 5

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(c3n2)C2(CCCC2)CNC4=O)nc1

InChI Key InChIKey=NSDIQCPIAXVCSR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 472678   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C](Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM472678(2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent