BDBM472103 (R)-5-(4-Isopropoxyphenyl)-4-oxo-N-(piperidin-3-yl)-4,5-dihydro-::US10822348, Example 405

SMILES CC(C)Oc1ccc(cc1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCNC4)c([nH]c1=O)c23

InChI Key InChIKey=DWDORWBIHRWDLV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 472103   

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM472103((R)-5-(4-Isopropoxyphenyl)-4-oxo-N-(piperidin-3-yl...)
Affinity DataIC50: 3.16E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM472103((R)-5-(4-Isopropoxyphenyl)-4-oxo-N-(piperidin-3-yl...)
Affinity DataIC50: 3.50E+3nMAssay Description:Binding affinity to recombinant unphosphorylated human GST-tagged BTK kinase domain (389 to 659 residues) expressed in insect cells incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed