BDBM471867 US10828300, Compound I-176::US11351168, Compound I-176

SMILES COc1ccc(Nc2ncc(C(=O)NC3CC3)c(Oc3cccc(NC(=O)C=C)c3)n2)cn1

InChI Key InChIKey=QEIQAACMXGKWSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 471867   

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM471867(US10828300, Compound I-176 | US11351168, Compound ...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM471867(US10828300, Compound I-176 | US11351168, Compound ...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM471867(US10828300, Compound I-176 | US11351168, Compound ...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM471867(US10828300, Compound I-176 | US11351168, Compound ...)
Affinity DataIC50: 550nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent