BDBM47183 US8975267, 16

SMILES CCc1cccc(CC)c1NC(=O)c1cn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21

InChI Key InChIKey=CNSGSATYYDDERW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47183   

TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM47183(US8975267, 16)
Affinity DataIC50: 132nMpH: 7.5Assay Description:The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
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TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM47183(US8975267, 16)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM47183(US8975267, 16)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent