BDBM471741 N4-(1,4-Benzoxazine-3-on-6-yl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine::US10828301, Compound R908702

SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc4OCC=Nc4c3)n2)c1

InChI Key InChIKey=HKDWIMXKTMEFQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 471741   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandPNGBDBM471741(US10828301, Compound R908702 | N4-(1,4-Benzoxazine...)
Affinity DataIC50: 37.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent