BDBM47139 US8952169, 175::US8952169, 295

SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F

InChI Key InChIKey=IKSUDZQUQOMVKP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 47139   

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 15.5nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 670nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 1nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed