BDBM470612 (1S,3′R,6′R,7′R,8′E,11′S,12′R)-6-chloro-7′-ethoxy-12′-(2-methoxyethyl)-11′-methyl-7′-((4-(1-methylethyl)-1-piperazinyl)methyl)-3,4-dihydro-2H, 15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.0-3,6˜.0˜19,24˜]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide::US10821115, Example 16::US11224601, Example 16

SMILES CCO[C@]1(CN2CCN(CC2)C(C)C)\C=C\C[C@H](C)[C@@H](CCOC)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=AGSIPPAZTGZIQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470612   

LigandPNGBDBM470612((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50: 0.0650nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
US Patent

LigandPNGBDBM470612((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50: 0.0650nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent