BDBM470606 US10821115, Example 10::US11224601, Example 10

SMILES CO[C@]1(CN2CCN3CCCC[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=BJTFTQIBRVBSBH-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 470606   

LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataIC50: 0.103nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataIC50: 0.103nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of recombinant His10-tagged human Bcl-2 (2 to 211 residues) using biotinylated Bim BH3 peptide as substrate incubated for 60 mins by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of recombinant His6-tagged human Bcl-xL (1 to 196 residues) expressed in Escherichia coli using biotinylated Bim BH3 peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed