BDBM470553 1-(4-[(2,6-difluorophenyl)carbamoyl]-3-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}phenyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylic acid::US10815215, Example 213::US11130745, Example 213::US11713304, Example 213

SMILES CCn1c(nn(-c2ccc(C(=O)Nc3c(F)cccc3F)c(O[C@@H](C)C(F)(F)F)c2)c1=O)C(O)=O

InChI Key InChIKey=PWJIQVMSPOHPLT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 470553   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470553(1-(4-[(2,6-difluorophenyl)carbamoyl]-3-{[(2S)-1,1,...)
Affinity DataIC50: 9nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470553(1-(4-[(2,6-difluorophenyl)carbamoyl]-3-{[(2S)-1,1,...)
Affinity DataIC50: 9nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470553(1-(4-[(2,6-difluorophenyl)carbamoyl]-3-{[(2S)-1,1,...)
Affinity DataIC50: 9nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent