BDBM469858 CIS-N-(4-Cyano-5-methylsulfanyl-1H-pyrazol-3-yl)-2-[1-(cyclobutyl-methyl)-8- dimethylamino-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-acetamide::US10807989, Example SC_1086

SMILES CSc1[nH]nc(NC(=O)CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1C#N

InChI Key InChIKey=RHMCZAURKQXHER-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 469858   

TargetNociceptin receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM469858(US10807989, Example SC_1086 | CIS-N-(4-Cyano-5-met...)
Affinity DataKi:  0.800nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMu-type opioid receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM469858(US10807989, Example SC_1086 | CIS-N-(4-Cyano-5-met...)
Affinity DataKi:  16.5nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent