BDBM469269 US10807985, Compound 44

SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1

InChI Key InChIKey=DWYRIWUZIJHQKQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 469269   

TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha [D842V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 1nMAssay Description:In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 1nMAssay Description:In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Dr. Harisingh Gour University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ABCG2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 5.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 10.8nMAssay Description:The PDGFRα enzyme assays were conducted per the manufacturer's directions (Promega PDGFRα Kinase Enzyme System and ADP Glo Assay Cat #V8011). Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 1.52E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 4.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed