BDBM468609 US10807944, Compound RLS3-43::US10870618, Compound 1e::US11731934, Compound SR-3558

SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=WRMLHFIPUNMIQC-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 468609   

TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 90nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 2.43E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 68.8nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMAssay Description:Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST-tagged human NCOR2 (395 to 489 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMAssay Description:Inhibition of C-terminal 6xHis-tagged full-length recombinant human HDAC2 (1 to 488 residues) expressed in Sf9 insect cells by Luminescence Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 1.31E+3nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 69nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 2.43E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent