BDBM468384 (S) N-(2′-chloro-3′-(1,5-dimethyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-2-carboxamido)-2-methylbiphenyl-3-yl)-5-(2-hydroxypropyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-2-carboxamide::US10806785, Example 24::US11596692, Compound P8

SMILES C[C@H](O)CN1CCc2c(C1)nc(C(=O)Nc1cccc(c1C)-c1cccc(NC(=O)c3nc4CN(C)CCc4n3C)c1Cl)n2C

InChI Key InChIKey=SGKGJQGTKWGUSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468384   

LigandPNGBDBM468384(US10806785, Example 24 | (S) N-(2′-chloro-3&...)
Affinity DataIC50: 0.550nMAssay Description:Binding assays were conducted in a low volume white 384-well polystyrene plate in a final volume of 20 μL. Compounds to be analyzed were first s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM468384(US10806785, Example 24 | (S) N-(2′-chloro-3&...)
Affinity DataIC50: 0.100nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Incyte

US Patent
LigandPNGBDBM468384(US10806785, Example 24 | (S) N-(2′-chloro-3&...)
Affinity DataIC50: 0.550nMAssay Description:Binding assays were conducted in a low volume white 384-well polystyrene plate in a final volume of 20 μL. Compounds to be analyzed were first s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM468384(US10806785, Example 24 | (S) N-(2′-chloro-3&...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed