BDBM468320 2-{3-[2-amino-6-(1,2,3,6- tetrahydropyridin-4-yl)- 7H-pyrrolo[2,3- d]pyrimidin-4-yl]- 2-(hydroxy- methyl)phenyl}-6- cyclopropyl- 8-fluoroisoquinolin- 1(2H)-one::US10793575, Example 93
SMILES Nc1nc(-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)c2cc([nH]c2n1)C1=CCNCC1
InChI Key InChIKey=DURVPEAYOPCPRO-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468320
Affinity DataIC50: 0.410nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair