BDBM468316 4-{2-amino-4-[3- (6-cyclopropyl-8- fluoro-1-oxoisoquinolin- 2(1H)-yl)-2- (hydroxymethyl)phenyl]- 7H-pyrrolo[2,3- d]pyrimidin-6-yl}-N,N- dimethyl-5,6- dihydropyridine-1(2H)- carboxamide::US10793575, Example 87

SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(nc(N)nc2[nH]1)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C1CC1

InChI Key InChIKey=NFJBREDEMVGORP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468316   

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.520nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Carna Biosciences

US Patent
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.950nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed