BDBM468314 2-{3-[2-amino-6- (1,1-dioxido-3,6- dihydro-2H- thiopyran-4-yl)- 7H-pyrrolo[2,3- d]pyrimidin-4-yl]- 2-(hydroxy- methyl)phenyl}-6- cyclopropyl- 8-fluoroisoquinolin- 1(2H)-one::US10793575, Example 83

SMILES Nc1nc(-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)c2cc([nH]c2n1)C1=CCS(=O)(=O)CC1

InChI Key InChIKey=LGOZFWQUICIAAM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 468314   

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM468314(US10793575, Example 83 | 2-{3-[2-amino-6- (1,1-dio...)
Affinity DataIC50: 0.25nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Carna Biosciences

US Patent
LigandPNGBDBM468314(US10793575, Example 83 | 2-{3-[2-amino-6- (1,1-dio...)
Affinity DataIC50: 0.580nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent