BDBM468313 2-(3-{2-amino-6- [1-(4-methylpiperazine-1- carbonyl)-1,2,3,6- tetrahydropyridin-4-yl]- 7H-pyrrolo[2,3- d]pyrimidin-4-yl}- 2-(hydroxy- methyl)phenyl)-6- cyclopropyl- 8-fluoroisoquinolin- 1(2H)-one::US10793575, Example 71
SMILES CN1CCN(CC1)C(=O)N1CCC(=CC1)c1cc2c(nc(N)nc2[nH]1)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C1CC1
InChI Key InChIKey=MJKMVJSOHIGIKI-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468313
Affinity DataIC50: 0.390nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair