BDBM467894 5-(*S)-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-((R)-1-((E)-4- ((4aR,7aS)-tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrol-6(3H)-yl)but-2- enoyl)pyrrolidin-3-yl)-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide;::US10800792, Example 555::US10822348, Example 555

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)C(=O)\C=C\CN4C[C@H]5OCCO[C@H]5C4)c([nH]c1=O)c23

InChI Key InChIKey=LUESPVNRWPACAF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 467894   

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467894(US10800792, Example 555 | 5-(*S)-(2-Methyl-4-pheno...)
Affinity DataIC50: 7.94nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467894(US10800792, Example 555 | 5-(*S)-(2-Methyl-4-pheno...)
Affinity DataIC50: 7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent