BDBM467748 (R)-5-(4-Isopropoxyphenyl)-4-oxo-N-(1-propionylpiperidin-3-yl)- 4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide;::US10800792, Example 406::US10822348, Example 406

SMILES CCC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(OC(C)C)cc4)c(=O)[nH]c1c23

InChI Key InChIKey=JOYZRBGNXAUKMX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 467748   

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467748(US10800792, Example 406 | (R)-5-(4-Isopropoxypheny...)
Affinity DataIC50: 6.31E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467748(US10800792, Example 406 | (R)-5-(4-Isopropoxypheny...)
Affinity DataIC50: 6.31E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467748(US10800792, Example 406 | (R)-5-(4-Isopropoxypheny...)
Affinity DataIC50: 6.60E+3nMAssay Description:Binding affinity to recombinant unphosphorylated human GST-tagged BTK kinase domain (389 to 659 residues) expressed in insect cells incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed